Preliminary treatment outcomes for 35 patients with stage T1–3N0–2M0 laryngeal and laryngopharyngeal cancer have been presented. Out of 35 patients, there were 30 with laryngeal cancer and 5 with laryngopharyngeal cancer. Combined modality treatment including preoperative radiation therapy was administered to 16 patients and radical radiotherapy (without surgery) was given to 19 patients. Radiotherapy response was assessed in patients treated with total doses of 40 Gy and 60 Gy. Local hyperthermia resulted no in expressed general and local reactions. Patients with laryngeal and laryngopharyngeal cancer and tumor regression of less than 50 % or stable disease underwent surgery. Histological examination revealed complete response in all cases. Patients with laryngeal and laryngopharyngeal cancer and tumor regression of more than 50 % received radical radiation therapy in combination with local hyperthermia. The analysis of treatment outcomes indicates that local hyperthermia allows the rate of complete response to be increased.

The purpose of the study was to analyze the relationship between expression of the р53, bcl-2 and bax genes and clinical-morphological parameters and survival in patients with non-small cell lung cancer (NSCLC). Expression of bcl-2 and р53 was found to be higher in patients with squamous cell carcinoma, bax expression was higher in patients with adenocarcinoma and bcl-2 level was higher in patients with stage I NSCLC and in patients having no lymph node metastases. Survival of patients with NSCLC depended on the expression of p53, bcl-2 and depended no on the bax expression. Survival rates were increased in bcl-2 expression and decreased in p63 expression. Survival rate of patients with NSCLC was higher in –p53/+bcl-2 and –p53/+bcl-2/–bax immune phenotypes and lower in +p53/+bax and +p53/–bcl-2/+bax immune phenotypes. The unifactor regression analysis showed that bcl-2 and р53 were prognostic factors. The multifactor regression analysis revealed no relationship between bcl-2, р53, bax and prognosis of NSCLC.

Breast cancer is the most common cause of death from cancer among women in Russia. More than half of patients have metastases at diagnosis. Chemotherapy is an important component of combined modality treatment for breast cancer. The budget impact analysis of expenses for the use of eribulina demonstrated that its inclusion in the «List of Essential Drugs» greatly expand the possibilities of treatment for metastatic breast cancer without causing significant additional burden on the health budget of the Russian Federation.

Purpose: to study serum adipokine levels and AdipoR1, AdipoR2 and sOb-R expressions with respect to clinical-morphological parameters and the evidence of metaboloc syndrome (MS) in patients with stage I–III colon cancer.

Materials and methods. The study included 31 colon cancer patients having metabolic syndrome and patients having no metabolic syndrome. Serum levels of leptin, adiponektin, AdipoR1, AdipoR2 and soluble form of the leptin receptor was assessed by ELISA.

Results and conclusion. The incidence of MS in colon cancer patients was 71 %. The relationship between the serum leptin level and gender and disease stage was revealed. The tendency toward increase in the leptin level in patients with MS was shown. The Ob-R level was higher in patients having no MS. The levels of AdipoR1 and AdipoR2 were significantly higher in female colon cancer patients. Adiponectin receptors tended to increase in colon cancer patients with MS.

The paper presents 4 cases of rare tumors in laboratory mice: mastocytoma of mandibular lymph node, megakaryocytic leukemia, splenic erythroblastoma (non-disseminated erythroleukemia) and splenic marginal zone lymphomas. The last 3 neoplasms were first diagnosed as spontaneous tumors in animals without genetic modification. Particular attention was drawn to the diagnostic features and characteristics of these tumors in comparison with the cases described in the literature.

The results of the effect of pulse-periodic X-ray exposure (PPXE) generated by Sinus-150 accelerator on tumor and normal cells of mice have been presented. Chromosomal aberrations (metaphase analysis) of bone marrow cells were studied. Using the cultured Lewis lung carcinoma cell lines, the level of apoptotic cells and cells with high concentration of active oxygen forms (AOF) was assessed by the flow cytofluorometry analysis (FACSCantoII, BD). In vivo X-ray radiation in the pulse-periodic mode lead to the moderate increase in chromosomal aberrations of bone marrow cells of mice. PPXE induced apoptotic death in Lewis lung carcinoma cells in vitro due to AOF production. Dose-effect relation was not observed at the irradiation doses 0.2–1.0 Gy. The data obtained show that further studies are necessary to justify the use of PPXE in tumor therapy.

A need to strengthen the lower uterine segment and the formation of «obturator» apparatus for carrying a subsequent pregnancy is one of the problems of transabdominal radical trachelectomy performed for patients with stage IA2–IB2 cervical cancer. Isthmo-cervical incompetence may lead to mechanical falling and prolapse of the fetal bladder, creating conditions for its infection. We have developed and tested a method for forming the obturator apparatus of the uterus at the level of the internal os. Usefulness of the mesh implant made of a superelastic titanium nickelid is due to its unique biomechanical properties and high biocompatibility. Regarding the problem of strengthening the utero-vaginal anastomosis, the implant takes over the basic function of the «obturator» apparatus of the uterus, providing functional support, and formed anastomosis to change intrauterine and intraperitoneal pressure.

The literature review examines the main pathological and morphogenetic aspects of the development of peritoneal carcinomatosis and its molecular and biological features. In addition, the basic principles of peritoneal carcinomatosis classification have been presented and groups of tumors, which may be complicated by dissemination to the peritoneum, have been designated. Particular attention is paid to the problems of diagnosis and treatment.

This review discusses current literature data on the surgical treatment of ovarian cancer, including optimal cytoreductive surgery (primary or intermediate), lymphadenectomy in metastatic ovarian cancer, combined operations, and the prospects for the use of laparoscopy in ovarian cancer.

This review of the literature is devoted to the analysis of wound infections in patients with urological cancer. Compared to data on urological infections, a few reports on wound complications have been available. The information on the resistance of pathogens is particularly relevant, since it significantly affects the choice and adequacy of antibiotic therapy, allowing the infection to be overcome as quickly as possible.

The review presents data on the ubiquitin-proteasome system participation in pathogenesis of gastric cancer. The role of proteasome system in regulation of cell cycle, angiogenesis and tumor metastasis has been shown. The aspects of the participation of ubiquitin-proteasome proteolytic system in the pathogenesis of intensive muscle protein degradation in cancer cachexia are analyzed. The role of proteasome system in the development of H. Pylori-induced gastric cancer is discussed. The clinical assessment of selective proteasome inhibitor (bortezomib) is a promising area of research for metastatic gastric cancer.

A case report of polyneoplasia in a male patient with induced breast cancer demonstrates current trends in drug therapy for multiple primary cancers.

Choriocarcinoma is a malignant neoplasm arising usually from the placenta. It is characterized by early hematogenous metastasis. Due to early metastasis and chemoresistance, patients with choriocarcinoma may have a poor prognosis. In this article we present a clinical case of choriocarcinoma in a young woman after childbirth. Important aspects of the history, clinical manifestations, diagnosis and management of patients with choriocarcinoma have been presented.

A rare clinical case of squamous cell lung cancer with metastases to the skin of the gluteal region after combined modality treatment has been presented. This case is of interest due to atypical localization of metastases, histological tumor type and disease prognosis.

A rare case of successful surgical treatment of giant MALT-lymphoma with Menetrier’s disease complicated by gastric obstruction has been presented.